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**Supplementation for Testosterone: The Sacred Substances.** It is important to preface this section with the following: Do not start trying to boost testosterone via supplements until most of what we have already mentioned above is set in place. You can spend hundreds on supplements, despite there being higher benefits from the lower-hanging fruit from areas such as perfecting sleep, reducing stress, reducing environmental toxins, and following the diet protocol. Supplementation does work, but you must focus your energy on the principles before this point first. Assuming now that you have the information above dialed in, here is how to effectively supplement to boost your testosterone even further... Here is a list of the substances I have found to be most effective. The issue is, however, that there are many different substances that you could use. You must therefore treat this section as a long-term experiment, as some of these substances may work amazingly for you, but not others. Try one for 6-8 weeks, get bloodwork done, and monitor your body to pick up on any benefits. Eventually, you will be able to compile a personal stack that you find most effective. Here is the list of substances: 1. Tongkat Ali 2. Fadogia Agrestis 3. Shilajit 4. Mucuna Pruriens 5. Boron 6. D-Aspartic Acid 7. Panax Ginseng 8. L-Carnitine 9. Coleus Forskohlii 10. Cistanche Tubulosa 11. Pine Pollen 12. Horny Goat Weed 13. Royal Jelly 14. Grapeseed Extract 15. Raw Ginger 16. Raw Carrots 17. Pomegranate Juice --- **Explanations and Methods of Action** **1. Tongkat Ali (Eurycoma longifolia):** Tongkat Ali is a potent herbal remedy that has been used in Southeast Asia for thousands of years. It works by increasing luteinizing hormone (LH) levels, which we know, stimulates the Leydig cells in the testes to produce more testosterone. Additionally, Tongkat Ali reduces sex hormone-binding globulin (SHBG), freeing more active testosterone in the bloodstream, leading to more of the desired characteristics of testosterone to actually be expressed. It also lowers cortisol, which we know is the direct antithesis to optimal testosterone. **Recommended dosage:** 200-400 mg daily of a standardized extract (100:1 ratio). Cycling is advised—5 days on, 2 days off, or 8 weeks on followed by a break. --- **2. Fadogia Agrestis:** Its primary mechanism of action for increasing testosterone is again by increasing the secretion of luteinizing hormone, boosting Leydig cell production of testosterone. **Recommended dosage:** 600-1,000 mg daily. We recommend cycling this substance (e.g., 4 weeks on, 2 weeks off) to prevent potential desensitization of the HPG axis. *Can be liver toxic to some - be wary of this* --- **3. Shilajit:** Shilajit is a mineral-rich resin found in high regions of mountains. It contains fulvic acid and other compounds that act as powerful antioxidants, which protect Leydig cells from oxidative stress. Shilajit also boosts mitochondrial function, aiding in the overall energy metabolism necessary for optimal testosterone synthesis. Shilajit increases total and free testosterone, as well as DHEA levels. Finally, this substance is super high in hundreds of different trace minerals which each play integral roles in the body and in testosterone production. **Recommended dosage:** 500 mg of purified Shilajit extract per day. It’s typically recommended for long-term use (8+ weeks) to see the best results. --- **4. Mucuna Pruriens** Mucuna Pruriens is a natural source of L-DOPA, the precursor to dopamine. By increasing dopamine, this substances reduces prolactin levels, which can otherwise suppress testosterone. It also supports the HPG axis, leading to enhanced production of LH and, consequently, testosterone. A nice side benefit of supplementing with this is improved mood and motivation aswell. **Recommended dosage:** 300-500 mg of a standardized extract with 15-20% L-DOPA content.Best used consistently for several months to experience notable improvements in testosterone and reproductive function. --- **5. Boron:** Boron is a trace mineral that has significant effects on testosterone regulation and androgen metabolism. Its ability to influence testosterone comes from its effects on sex hormone-binding globulin (SHBG), free testosterone, and its anti-inflammatory properties. Boron significantly reduces SHBG, the protein that binds to testosterone in the bloodstream, making it inactive. By lowering SHBG, boron increases the levels of free, bioavailable testosterone, which is what exerts the anabolic and desired characteristics that we are after. Boron helps balance the testosterone-to-estradiol ratio by optimizing estrogen metabolism. It decreases the conversion of testosterone into estradiol by inhibiting the aromatase enzyme, further preserving testosterone levels. **Recommended dosage:** 6-10 mg daily, with studies showing significant increases in free testosterone and reductions in SHBG and estrogen at 10 mg. --- **6. D-Aspartic Acid (DAA):** D-Aspartic Acid is an amino acid that it stimulates the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus, which you know, increases LH. Higher LH levels lead to increased testosterone production from the Leydig cells in the testes. Aswell as this boost in LH, it also makes the leydig cells more sensitive to LH, improving production further. Finally, DAA upregulates the expression of StAR protein, which facilitates the transport of cholesterol into the mitochondria of Leydig cells. Since cholesterol is the precursor of testosterone, this action directly enhances steroidogenesis and testosterone synthesis. **Recommended dosage:** 2,000-3,000 mg daily, often cycled (e.g., 12 days on, followed by 1 week off) to avoid potential desensitization of the LH receptors. --- **7. Panax Ginseng:** Panax Ginseng is an adaptogenic herb that has been used for centuries to enhance energy and overall vitality. It contains substances called ginsenosides, which stimulate the hypothalamus to release GnRH, increasing LH and testosterone production downstream. Similarly, as an adaptogen, Panax Ginseng helps reduce stress and lower cortisol levels, both of which are detrimental to testosterone. Finally, it also increases nitric oxide levels, which improves blood flow and vascular health. Better circulation to the testes and other tissues supports healthy testosterone synthesis. **Recommended dosage:** 200-400 mg daily of a standardized extract with 5-7% ginsenosides. Best used in cycles of 6-8 weeks to prevent tolerance build-up. --- **8. L-Carnitine:** L-Carnitine increases the density of androgen receptors in muscle cells, making the tissues in the body more responsive to testosterone. Even without increasing serum testosterone, L-Carnitine improves the body’s ability to utilize the testosterone that is available. Similarly, testosterone production requires functional mitochondria, as these organelles are responsible for producing the energy needed for steroidogenesis. L-Carnitine enhances mitochondrial efficiency, supporting the Leydig cells in synthesizing more testosterone. **Recommended dosage:** 2,000-3,000 mg daily, typically in the form of L-Carnitine L-Tartrate (LCLT), which is more bioavailable and commonly used for hormonal support and athletic performance. --- **9. Coleus Forskohlii (Forskolin):** Coleus Forskohlii is an herb that contains the active compound ****forskolin**.** Forskolin directly stimulates the enzyme adenylate cyclase, which increases the levels of cyclic adenosine monophosphate (cAMP) in cells. By raising cAMP levels, it boosts luteinizing hormone (LH**)** and thus testosterone. The rise in cAMP also stimulates the expression of enzymes involved in steroidogenesis, which we know is the process by which cholesterol is converted into testosterone. This includes the upregulation of StAR which increases the transport of cholesterol into the mitochondria. **Recommended Dosage:** 250-500 mg of Coleus Forskohlii standardized to 10-20% forskolin, taken 1-2 times daily. --- **10. Cistanche Tubulosa:** This substance stimulates Leydig cell activity whilst enhancing the enzymatic pathways within steroidogenesis involved in converting cholesterol into testosterone. As an adaptogen as well, it helps regulate stress and reduce cortisol levels. Finally, Cistanche boosts nitric oxide levels, improving blood flow to the testes and supporting the function of the testes in producing testosterone. **Recommended Dosage:** 500-1500 mg of standardized extract, taken 1-2 times daily. --- **11. Pine Pollen:** Pine Pollen is unique because it contains phytoandrogens. These areplant-based compounds that mimic the function of testosterone. These compounds are bioidentical testosterone as well as DHEA (Dehydroepiandrosterone), androstenedione, and androsterone, meaning that they can bind to androgen receptors, increasing androgenic activity in the body. **Recommended Dosage:** 1-3 grams of powder or 1-2 dropperfuls of tincture, taken daily. --- **12. Horny Goat Weed (Epimedium):** Horny Goat Weed contains the active compound icariin. This is a natural inhibitor of PDE5, which increases nitric oxide (NO) levels and enhances blood flow. This increased NO improves testicular blood flow, enhancing testosterone production. This substance also increases the release of LH, whilst increasing androgen receptor sensitivity in cells, enhancing the effects of your current levels of testosterone. **Recommended Dosage:** 500-1000 mg of standardized extract with 10-20% icariin, taken daily. --- **13. Royal Jelly:** Royal Jelly is a secretion used by bees to nourish queen bees and is something that I highly recommend for testosterone and general health due to its abundant nutrient content, of various vitamins, minerals and hormones. One of the ways that it boosts testosterone is because it boosts luteinizing hormone (LH) and follicle-stimulating hormone (FSH), ****both of which increase testosterone production. Similarly, Royal Jelly contains compounds that support the conversion of cholesterol into pregnenolone, the precursor for all steroid hormones, including testosterone. This enhances overall steroidogenesis and testosterone production. Royal Jelly also has powerful antioxidant properties, which reduce oxidative stress in the testes, reducing free radical damage, and thus improving testosterone synthesis. The list of benefits goes on for Royal Jelly... It also increases androgen receptor sensitivity, which we have discusessed the benefits of, whilst reducing systemic inflammation and cortisol, both of which are testosterone inhibiting. **Recommended Dosage:** 500-1000 mg of raw and organic royal jelly, taken daily and on an empty stomach in the morning, sublingually. --- **14. Grapeseed Extract:** Grapeseed extract is rich in proanthocyanidins, which are powerful antioxidants. This high antioxidant content reduces oxidative stress in the testes, protecting Leydig cells and supporting testosterone production. It also contains compounds that inhibit the aromatase enzyme which means you will get less conversion of testosterone into estrogen. Finally, by promoting better blood flow through its antioxidant and anti-inflammatory properties, grapeseed extract improves the delivery of nutrients and oxygen to the testes, **Recommended Dosage**: 150-300 mg of standardized extract (95% proanthocyanidins) daily. --- **15. Raw Ginger:** Ginger contains bioactive compounds like gingerol and zingerone, which increase testosterone. They do so by stimulating the release of luteinizing hormone (LH), which signals the testes to produce more testosterone and increasing the activity of antioxidant enzymes like glutathione, reducing oxidative stress in the testes. Finally, ginger improves the conversion of cholesterol into pregnenolone, the precursor to testosterone whilst being a potent anti-inflammatory, promoting a healthier environment for testosterone synthesis. **Recommended Dosage:** 1-2 grams of fresh, organic ginger root daily. --- **16. Raw Carrots:** Carrots are rich in insoluble fiber, which bind to excess estrogen in the digestive tract and facilitate its excretion. By reducing estrogen levels, the body maintains a better testosterone-to-estrogen ratio. Carrots also contain carotenoids, which have anti-estrogenic properties that can prevent the excessive conversion of testosterone into estrogen. **Recommended Intake:** 1-2 raw carrots per day. Best consumed on an empty stomach or between meals for better estrogen detoxification. --- **17. Pomegranate Juice** A glass of cold-pressed pomegranate juice per day is all you need. This stuff is incredibly high in antioxidants on polyphenols which reduce oxidative stress (protecting leydig cells and reducing inflammation). Similarly, pomegranate juice actually lowers cortisol, improves blood flow and inhibits aromatase. The final benefit to mention of this miracle juice is that increases the 5a-reductase enzyme, boosting DHT. *(More on this in future guides, stay tuned...)* **Recommended Intake:** 300ml of freshly squeezed (ideally done at home with a juicer) juice per day.